Brief Report LYMPHOID NEOPLASIA Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels
نویسندگان
چکیده
Service d’Anatomie et Cytologie Pathologiques, Centre Hospitalier Universitaire, Hôtel Dieu, Nantes, France; Swiss Institute of Bioinformatics, Bȃtiment Genopode, Lausanne, Switzerland; Département de Pathologie, Hôpital Pessac, Bordeaux, France; Département de Pathologie, Hôpital Purpan, Toulouse, France; Unité Hémopathies Lymphoı̈des, Groupe Henri Mondor Albert-Chenevier, Assistance Publique – Hôpitaux de Paris, Créteil, France; Service d’Anatomie et Cytologie Pathologiques, Hôpital Avicenne, Bobigny, France; Département d’Anatomie Pathologique, Hôpital Saint Antoine, Assistance Publique – Hôpitaux de Paris, Paris, France; Service d’Hématologie, Hôpital Necker, Assistance Publique – Hôpitaux de Paris, Paris, France; Service de Thérapie Cellulaire et d’Hématologie Clinique Adulte, Université d’Auvergne, Inserm Centre d’Investigation Clinique 501, Centre Hospitalier Universitaire Clermont-Ferrand Hôpital Estaing, Clermont-Ferrand, France; Ludwig Center for Cancer Research, and Oncology Department, University of Lausanne, Lausanne, Switzerland; Département de Pathologie, Groupe Henri-Mondor Albert-Chenevier, Assistance Publique – Hôpitaux de Paris, Créteil, France; Inserm U955, Créteil, France; Université Paris Est, Créteil, France; and Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
منابع مشابه
Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels.
The extended use of brentuximab-vedotin was reported for CD30(+) nonanaplastic peripheral T-cell lymphomas (PTCLs) with promising efficacy. CD30 status assessment is thus a critical factor for therapeutic decision, but the reliability of immunohistochemistry (IHC) in evaluating its expression remains to be defined. This prompted us to investigate the correlation between semiquantitative CD30 pr...
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1. Schwab U, Stein H, Gerdes J et al. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin’s disease and a subset of normal lymphoid cells. Nature 1982; 299; 65–67. 2. Younes A, Gopal AK, Smith SE et al. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin’s lymphoma. J. Clin. Oncol. 2012; 30; 2183–21...
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Primary cutaneous CD30+ T cell lymphoma is rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is a good and has a good response to radiotherapy. We report a 34- year- old man who had primary cutaneous CD30+T cell lymphoma on his face, which presented as an ulcerated nodule.
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